ST-Elevation Myocardial Infarction (STEMI): Loading dose: 300 mg orally once (OPTIONAL) Maintenance dose: 75 mg orally once a day, with or without
Methods and Results— Patients treated long term by clopidogrel 75 mg/d were assigned to receive a first loading dose of 300, 600, or 900 mg clopidogrel and 4
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The primary null hypothesis of the trial is that in subjects with TIA or minor ischemic stroke treated with aspirin 50–325 mg/day, there is no difference in the event-free survival at the Day 90 follow-up in those treated with clopidogrel (600 mg loading dose then 75 mg/day) compared to placebo when subjects are randomized within 12 hours of In patients who need an antiplatelet effect within hours, initiate Plavix with a single 300 mg oral loading dose and then continue at 75 mg once daily
Subjects are randomized to clopidogrel (600 mg loading dose followed by 75 mg/day) or matching placebo, and all will receive open-label aspirin 50-325 mg/day, with a dose of 162 mg daily for These results are consistent with those found in CHANCE, a similar trial that randomly assigned patients to 90-day treatment with aspirin or to clopidogrel-aspirin for 21 days followed by clopidogrel alone
Background— Pretreatment with clopidogrel can reduce the risks associated with percutaneous coronary intervention (PCI)
The clopidogrel plus aspirin group received a 600 mg loading dose of clopidogrel, followed by 75 mg daily from day 2 to day 90
Duration of therapy: Optimal duration unknown
The primary outcome of major ischemic ACC/AHA guidelines recommend clopidogrel loading dose of 300 or 600 mg, followed by 75 mg daily in patients with NSTE-ACS who are treated with an early invasive or ischemia-guided strategy
In the acute phase people dual antiplatelet therapy is likely to be prescribed for 3-4 weeks: Clopidogrel (300 mg initial dose, then 75 mg daily) plus aspirin (300 mg initial dose, then 75 mg daily for 21 days) followed by long-term clopidogrel Rifampin: Coadministration of rifampin 300 mg twice daily for 7 days with 600 mg loading dose of clopidogrel in healthy adults increased the mean AUC and C max of clopidogrel's thiol metabolites by 3
These results are consistent with those found in CHANCE, a similar trial that randomly assigned patients to 90-day treatment with aspirin or to clopidogrel-aspirin for 21 days followed by clopidogrel alone
Indications and Dosage
Clopidogrel 300 to 600 mg loading dose followed by 75 mg daily [Strong recommendation; High quality of evidence]
Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease)