coli SE11 pSE11-1 tet(C) gene
Gene ID: 45093761, updated on 23-Apr-2023 Summary Other
coli SE11 pSE11-1 tet(C) gene encoding tetracycline efflux MFS transporter
tetracycline efflux MFS transporter Tet(64) Effective antibiotic transport has now been observed for many classes of drug efflux pumps
Based on Antibiotic toxin exposure, efflux can operate quickly and is the
Efflux pumps are found in almost all bacterial species and genes encoding this class of proteins can be located on chromosomes or plasmids [1], [2]
QacA and QacB are MFS transporters, both 514 amino acids long and 55 kDa in size, Expression of the Tet38 tetracycline efflux pump has been demonstrated to be negatively regulated at the level of transcription by MgrA, a global regulator, by an indirect means
The table
In this study, we have identified an efflux pump from Streptomyces coelicolor, SCO4121, belonging to the major facilitator superfamily (MFS) family of transporters and characterized its role in antibiotic resistance
Bacteriol
The Tet(63) protein is a member of the MFS of transporters and confers resistance to tetracycline and doxycycline while reducing bacterial susceptibility to minocycline
0
Whereas drug access into the binding pocket(s) of the tripartite ABC and MFS transporters is considered to be from the cytoplasmic side (or IM inner leaflet), the RND-type multidrug efflux Antibiotic-specific efflux pumps appear to be restricted to those organisms producing antibiotics and are often an integral part of the corresponding biosynthetic pathway
The tetracycline transport rate obtained with 200 μg/ml tetracycline and 0 μM EB (or another drug) was 1
The trans-envelope complex consists of transporters that span the entire envelope to export the substrates directly
(2002) published the first crystal structure of and an RND-type transporter AcrB